Clinical Services & Strategic Programs

The Strategic Programs Office of Pathology ACP garners collaborations between institutions and allows clinicians and scientists to work closely in research and development through different platforms. Examples of ongoing platforms include:

 

POLARIS @ SingHealth

SP1

A collaboration between SingHealth and Genome Institute of Singapore (GIS, A*STAR), Personalised OMIC Lattice for Advanced Research and Improving Stratification (POLARIS)@SingHealth allows clinicians and scientists to work closely from both campuses. It is a platform to partner with industry and academic groups in translational biomarker projects and enables the clinical use of genomic technologies in cancer and genetic diseases.

POLARIS utilises the Next Generation Sequencing (NGS) technology in the laboratories to conduct tests. This is a fundamentally different approach to sequencing and has the ability to trigger ground-breaking discoveries, igniting a revolution in genomic science.

POLARIS is currently developing a clinical assay for corneal dystrophy. Gastrointestinal and lung cancer panels are also in development stages.

To find out more about POLARIS at SingHealth, or how you could help, please contact polaris@singhealth.com.sg

 

CTC Centre of Research Excellence

SP2

Circulating Tumour Cell Center of Research Excellence (CTC CoRE) was established in January 2014 as a result of a collaborative effort between National Cancer Centre Singapore (NCCS) and Clearbridge BioMedics, in partnership with the Pathology Department of Singapore General Hospital (SGH). CTC CoRE is located in the newly-opened Academia building situated in SGH. It is fully equipped with the cytology, cytogenetic, histology and molecular biology platform. 

The aim of CTC CoRE is to provide an accurate, fast, economical and non-invasive cancer diagnosis using blood biopsy. In future, we hope blood biopsy can be used as a surrogate biomarker for biopsy which is useful to replace the conventional surgery and CT scan procedures currently used to monitor patients’ response to treatment.

A simple blood draw of 7.5 ml is sufficient for a CTC test using the ClearCell®-FX system to separate circulating tumour cells from other blood components. Using cytology and cytogenetics techniques, the number of cancer cells can be enumerated and documented. Potential applications include tracking mutation patterns in cancer cells across the time of treatment using the next generation sequencing facility at POLARIS laboratory.

CTC CoRE hopes to provide data to facilitate clinicians to effectively monitor patients’ response to therapy and better management of the cancer therapy program. Currently, CTC CoRE research and development team is driven towards developing a service for “CTC test” by end of the year which will be the first servicing center for CTC isolation, enumeration and characterization in Singapore and Asia using a platform technology developed locally.

 

You may read about the media release here.

 

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