Research

The Research Office of Pathology ACP provides administrative support to allow our researchers to focus on research activities with the ultimate aim of improving patient care. Some of the research activities in Pathology ACP are as follows:

Path ACP Research1

 

Research Activities

Ongoing Projects in Pathology ACP*

Researchers from Pathology ACP Role in Project Project Title Other Collaborating Institution(s)/ Department(s)
Dr Loo Liat Hui
Principal Scientific Officer Microbiology, KKH
Principal Investigator Analysis of Mutations in the 23S rRNA gene of Clinical Isolates of Mycoplasma pneumoniae causing Macrolide Resistance NA
Dr Chang Tou En Kenneth
Senior Consultant
Histopathology, KKH
Co-Principal Investigator Humanized Mouse Models For Studying Human Infectious Diseases, Cancers and Wound Healing IMCB (A*STAR)
Dr Chang Tou En Kenneth
Senior Consultant
Histopathology, KKH
Principal Investigator Molecular Analysis of Paediatric Tumours Duke-NUS
Dr Chang Tou En Kenneth
Senior Consultant
Histopathology, KKH
Site-Principal Investigator Cancer Stem Cell, Oncogenic Pathways and Modeling of Human Neuroblastoma and other Cancers IMCB (A*STAR)
Dr Sng Li-Hwei
Senior Consultant,
Central Tuberculosis Lab, SGH
Principal Investigator

Transmission Dynamics of Tuberculosis in Singapore: Universal Molecular Genotyping of Archived Mycobacterium Tuberculosis Complex Isolates complementing Classical Epidemiology

MOH STEP Registry (TTSH),
GIS (A*STAR),
NUHS,
SSHSPH (NUS)
Dr Chen Chuanfei
Scientific Officer
Cytogenetics, SGH
Principal Investigator Interrogating the Genomic Profiles of CD34+ and CD34- Acute Myeloid Leukaemia and Myelodysplastic Syndrome in a Clinical Setting NA
A/Prof Koh Tse Hsien
Senior Consultant
Diagnostic Bacteriology, SGH
Principal Investigator Exploring the Evolutionary Relationships between K1 Klebsiella pneumoniae isolated from Vegetables, Gastrointestinal Colonization, and Clinical Specimens DSO, NEA, GIS (A*STAR), Duke-NUS
Dr Syed Salahuddin Ahmed
Consultant
Histopathology, SGH
Principal Investigator Epithelial-Mesenchymal Transition and Epithelial-Stromal Interaction in Phyllodes Tumour: Clinical Relevance and Prognostic Significance NA
A/Prof Lim Kiat Hon Tony
Senior Consultant Histopathology, SGH
Co-Principal Investigator The POLARIS Programme - Transforming Disease Management through Personalised OMIC Profiling GIS, BTI (A*STAR), NUHS, NCCS & SNEC
A/Prof Lim Kiat Hon Tony
Senior Consultant Histopathology, SGH
Co-Principal Investigator Pre-clinical Validation of Clearcell-FX system and Downstream Integration of FISH Probes and Circulating Tumour Cells Enumeration Clearbridge Biomedics & NCCS
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Principal Investigator Biological Markers of Prognostic Importance in Phyllodes Tumours of the Breast IBN (A*STAR) & NCCS
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Principal Investigator Phyllodes Tumours/Fibroadenomas of the Breast: Biological Markers and Molecular Genetics NCCS
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Principal Investigator Stratification of Triple Negative Breast Cancer into Clinically Relevant Groups Duke-NUS, NCCS, NUHS
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Co-Investigator Mutational Analysis in Phyllodes Tumours of the Breast NCCS & Duke-NUS
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Co-Investigator WBP2 Expression in Ductal Carcinoma In Situ Dept of Biochemistry (NUS)
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Collaborator B3-H7 Expression in Triple Negative Breast Cancer SIgN (A*STAR)
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Collaborator Biomarker Discovery in Bladder Cancer NCCS
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Collaborator Biomarker Discovery in Renal Cell Carcinoma Dept of Urology (SGH)
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Collaborator Biomarkers in Invasive Breast Cancer Dept of Anatomy (NUS)
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Collaborator Molecular Profiling of Metastatic Lesions from Breast Cancer NCCS
Prof Tan Puay Hoon
Senior Consultant (Histopathology) & HOD (Pathology), SGH
Collaborator pAKT, NF1 and MAPK Expression in Invasive Breast Cancer Dept of Medical Oncology (NCCS)
Dr Wong Chui Ching Judith
Scientific Officer
Virology, SGH
Principal Investigator Development of a Bead-Based Immunofluorescence Assay for Respiratory Virus Antigen Detection NA

*This table lists some of the research projects undertaken by Pathology ACP researchers from KKH Department of Pathology and Laboratory Medicine and SGH Department of Pathology.

 

Pathology ACP Pitch-for-Funds Grant

The Pathology ACP Pitch-for-Funds Grant aims to promote laboratory-based research within Pathology ACP especially among junior doctors (residents/trainees) and junior scientific/technical staff.

The grant award will allow them to acquire experience in applying for grants, study design, project work, writing papers and presenting their data at an early stage of their career. It may also be used to jump start laboratory studies providing pilot data leading on to external and national grant funding. 

We congratulate the following successful awardees and wish them every success in their research endeavors!

We would also like to thank their mentors for their invaluable support and guidance!

 

Awardees Project Details
Dr Deborah Lai
Resident, SGH Dept of Anatomical Pathology

Project Title:
Role of the reverse Warburg effect in tumorigenesis in Cervical Intra-epithelial Neoplasia

Project duration:
1 Jul 2014 - 30 Sep 2016

Mentor(s):
-
Dr Sangeeta Mantoo
  Consultant, SGH Dept of Anatomical Pathology

- Dr Sophie Bellanger
  IMB, A*STAR

Dr Timothy Tay
Resident, SGH Dept of Anatomical Pathology

Project Title:
Pilot study to investigate the accuracy of p16/Ki-67 immunocytochemical dual stain in detecting Cervical Intraepithelial Neoplasia (CIN) when applied to Papanicolou (Pap) cervical smears with atypical squamous cytology

Project duration:
1 Jul 2014 - 31 Mar 2016

Mentor(s):
Dr Sangeeta Mantoo
Consultant, SGH Dept of Anatomical Pathology

Dr Tan Yen Ee
Associate Consultant, SGH Dept of Microbiology
Project Title:
First survey of antibiotic susceptibility of anaerobic bacteria in a large tertiary hospital in Singapore

Project duration:
1 Jul 2014 - 31 Dec 2015

Mentor(s):
Dr Tan Ai Ling
Senior Consultant, SGH Dept of Microbiology

Dr Soo Kai Ling
Associate Consultant, SGH Dept of Anatomical Pathology
Project Title:
Molecular profiling of Multiple Myeloma (MM) using Cytogenomic Microarray Analysis (CMA) with enriched plasma cell (PCs) populations

Project duration:
1 Oct 2015 - 30 Sep 2017

Mentor(s):
- A/Prof Tony Lim
  Head & Senior Consultant, SGH Dept of Anatomical Pathology

- A/Prof Alvin Lim
  Assistant Director, SGH Dept of Molecular Pathology

- Dr Sathish Kumar Gopalakrishnan
  Consultant, SGH Dept of Haematology

Dr Tracy Loh
Resident, SGH Dept of Anatomical Pathology
Project Title:
Using next generation sequencing (NGS) for the detection of genetic alterations on FFPE and its application on detection of common mutations in patients with dual primary malignancies.

Project duration:
1 Oct 2015 - 30 Sep 2017

Mentor(s):
- Dr Ronald Goh
  Consultant, SGH Dept of Anatomical Pathology

- A/Prof Tony Lim
  Head & Senior Consultant, SGH Dept of Anatomical Pathology

Dr Lim Kok hing
Registrar, SGH Dept of Anatomical Pathology
Project Title:
Validating a suitable immunocytochemical protocol for the detection of circulating tumour cells

Project duration:
1 Oct 2015 - 30 Sep 2017

Mentor(s):
-
A/Prof Tony Lim
  Head & Senior Consultant, SGH Dept of Anatomical Pathology

- Dr Angela Takano
  Senior Consultant, SGH Dept of Anatomical Pathology

Mr Jeffrey Lim
Medical Technologist, SGH Dept of Anatomical Pathology
Project Title:
Multiplex immunofluorescence approach to study tumour infiltrating lymphocytes: A breast cancer paradigm

Project duration:
1 Jan 2016 - 30 Jun 2017

Mentor(s):
Dr Syed Salahuddin Ahmed
  Senior Consultant, SGH Dept of Anatomical Pathology

- Prof Tan Puay Hoon
  Chairman & Senior Consultant, SGH Div of Pathology

- Dr Aye Aye Thike
  Senior Medical Laboratory Scentist, SGH Dept of Anatomical Pathology

Dr Deborah Lai
Medical Officer, SGH Dept of Microbiology
Project Title:
Metabolic changes in host cells during influenza virus infections

Project duration:
1 Oct 2017 - 31 Mar 2019

Mentor(s):
Dr Chan Kwai Peng
Senior Consultant, SGH Dept of Microbiology

Dr Dominique Seow
Medical Officer, SGH Dept of Anatomical Pathology
Project Title:
Multiplex immunofluorescence approach to study tumour-inflitrating lymphocytes in Triple-Negative Breast Cancer

Project duration:
1 Oct 2017 - 31 Mar 2019

Mentor(s):
Dr Jabed Iqbal
Senior Consultant, SGH Dept of Anatomical Pathology

Ms Clara Ong
Research Officer I, SGH Dept of Anatomical Pathology
Project Title:
Study of Janus Kinase 2 (JAK2) genomic alterations and potential role as biomarker in Triple Negative Breast Cancer

Project duration:
1 Oct 2017 - 31 Mar 2019

Mentor(s):
Dr Jabed Iqbal
  Senior Consultant, SGH Dept of Anatomical Pathology

- A/Prof Alvin Lim
  Assistant Director, SGH Dept of Molecular Pathology

- Dr Joe Yeong
  Senior Medical Research Fellow, Singapore Immunology Network, A*STAR

Ms Marybeth Tan
Medical Laboratory Technologist I, SGH Dept of Microbiology
Project Title:
A study on dengue virus susceptibility to Itraconazole

Project duration:
1 Oct 2017 - 31 Mar 2019

Mentor(s):
Dr Chan Kwai Peng
  Senior Consultant, SGH Dept of Microbiology

- Dr Puong Kim Yoong
  Senior Medical Laboratory Scientist (Clinical), SGH Dept of
  Molecular Pathology

 

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